Welcome to the GPCR-OKB

The GPCR-OKB is an information management system that allows browsing, visualization, and structured querying of computational and experimental information about G Protein-Coupled Receptor (GPCR) oligomerization, thus supporting productive and quantitative communication between computational and experimental scientists working in the field.

Although many biochemical and biophysical data are consistent with the ability of monomeric receptors to activate heterotrimeric G-proteins, more and more experimental evidence indicates that GPCRs can form either homo-oligomers or hetero-oligomers. For simplicity, GPCR-OKB will refer to GPCR oligomers, although direct evidence for higher-order oligomerization is not available yet for most receptors.

Database content as of November 2009:
Number of Oligomers: 124
Number of Oligomers/all GPCRs: 78/1493
Total number of Studies: 442
Total number of Pubmed articles: 143

Reference: "Requirements and ontology for a G protein-coupled receptor oligomerization knowledge base." BMC Bioinformatics. 2007 May 30;8:177. Skrabanek L, Murcia M, Bouvier M, Devi L, George SR, Lohse MJ, Milligan G, Neubig R, Palczewski K, Parmentier M, Pin JP, Vriend G, Javitch JA, Campagne F, Filizola M.